If you are running out of room to store locally cached profiles, in %SystemRoot%\Profiles\ on your workstation, and you want to store as many as possible, you can configure the ProfileImagePaths on the workstation.
NOTE: If you don't want to store locally cached profiles, see tip 106.
Use Regedt32 to navigate to:
For each user who has logged on, there will be a SID sub-key and a Value Name of ProfileImagePath.
Change the string value to point to a folder on another partition.
Copy the profiles you want to keep from %SystemRoot%\Profiles\ to the new location and remove them from %SystemRoot%\Profiles. Remove cached profiles that you don't want to keep.
Shutdown and restart the workstation.
NOTE: If you copy the profile, your user may receive a "locally cached profile is newer" message.
You don't have to copy the profile as the next user logon will re-cache it.
If you don't copy it, delete the old one from %SystemRoot%\Profiles\.