When you use Control Panel / Add/Remove Programs / Add/Remove Microsoft BackOffice Small Business Server, you may receive The application could not initialized.
If you run Startsam.exe, you would get the same error message.
This is caused because the SBS install files have been replaced, probably by NTOP.
To fix the problem:
rename sysocmgr.exe sysocmgr.old
rename ocmanage.dll ocmanage.old
Mount the SBS CD-ROM 1.
Expand <CD-ROM:>\i386\sysocmgr.ex_ sysocmgr.exe
Expand <CD-ROM:>\i386\ocmanage.dl_ ocmanage.dll
NOTE: You may need to reconfigure the NTOP using Sysocmgr.exe, if you did not do a default installation.