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When ASP.NET application is deployed in a Webfarms,most likely we get webservice time out erros in some server on the farm.

The underlying connection was closed: Unable to connect to the remote server

The  •Problems arise with  inter-cluster communications.

•If a node sends a request to a VIP whose nodes are on the same network, the response will not be routed back through BigIP.
•Separate networks for nodes that need to communicate with another VIP solve the issue.

Resolution is to simply enable SNAT for the IIS Farm pool, which allowed for proper communication.

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