Q. How can I stop Microsoft System Center Configuration Manager (SCCM) site systems from storing data on certain partitions?

A. By default, SCCM will use NTFS drives that have space on them. However, if you have drives you don't want SCCM to use, you can stop it by placing an empty file named no_sms_on_drive.sms on the root of the partition that shouldn't have SCCM content.

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