If you are using Internet Explorer 6 and you press Install or Run on a Web page that uses ClickOnce technology to deploy an application over the Internet, or intranet, the Setup program does not respond and you do not receive an error.
NOTE: If you try to install the ClickOnce application from the Web server, the Setup program runs properly.
This behavior occurs because the Internet Explorer security setting for the Run components not signed with Authenticode option under .NET Framework-Reliant Components is set to Disabled or Prompt, preventing the client from installing ClickOnce applications over the Internet or intranet.
To change this behavior, set the Internet Explorer 6 Run components not signed with Authenticode option under .NET Framework-Reliant Components to Enabled, even though this increases your security risk:
1. Start Internet Explorer.
2. On the Tools menu, press Internet Options.
3. Select the Security tab.
4. Press the Custom Level button.
5. Check the Enable radial button under Run components not signed with Authenticode.
6. Press OK.
7. If prompted, press Yes to confirm the setting change.
8. Press OK.