Microsoft Knowledge Base Article 323541 contains the following summary:
This step-by-step article describes how to set up accessibility for the mobility impaired in a Windows 2000 environment.
People who have motion-related disabilities can use Windows 2000 to configure their computer to provide a more comfortable
computing environment and help minimize the impact of mobility impairments on their work.
The Keyboard tool in Control Panel provides keyboard layouts for users of alternative keyboards. This is especially useful for users who type with one hand.
The Mouse tool in Control Panel configures the mouse for right- or left-handed users, adjusts double-click speed, pointer speed, and acceleration, and causes the mouse pointer to go directly to default buttons in dialog boxes.