When Windows Defender definitions are updated in Windows 2000, either manually, or because you configured it to automatically check for new definitions, you receive:
0x80240022 - the wrong diskette is in the drive. Insert %2 (Volume Serial Number: %3) into drive %1.
To workaround this behavior, use Windows Update to scan the computer and select Software, Optional for a root certificate update.
NOTE: To learn more about how adding additional root certificates to your computer lets more applications work, see Microsoft Root Certificate Program Members